Natural deep eutectic solvents (NADESs), composed of natural primary metabolites,\nare now widely used as green and sustainable extraction solvents of bioactive components.\nIn the present study, various NADESs were prepared to extract multi-components from different\npreparations of an herbal formula (Chinese name: Jinqi Jiangtang, JQJT) using ultrasound-assisted\nextraction (UAE). Results showed that most prepared NADESs provided more effective extraction of\nphenolic acids and alkaloids from JQJT preparations than conventional solvents. Among the tested\nNADESs, the solvent formed by choline chloride and laevulinic acid was selected to optimize the\noperational parameters using response surface methodology. The optimized extraction method\nwas successfully applied to extract six major components in four commercial JQJT products,\nand quantification analysis was performed by the validated high-performance liquid chromatography\nwith ultraviolet detection (HPLC-UV) method. The quantitative results indicated that preparations\nfrom different manufacturers showed different chemical profiles. In conclusion, NADESs-based\nUAE shows considerable potential as an efficient and green method for extraction of multi-bioactive\ncomponents from commercial herbal preparations.
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